AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:


Mutation site L443R/Y777D
Virus SARS-CoV
Mutation level Amino acid level
Gene/protein/region type S protein
Gene ID 1489668
Country -
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample cell line
Variants
Viral reference sequence AY278741.1
Drug/antibody/vaccine MAb S3.1 resistant
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation Yes
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:


Protein name spike glycoprotein
Uniprot protein ID P59594
Protein length 1255 amino acids
Protein description The spike protein of SARS coronaviruses is a protein composed of three polypeptide chains and it contains two domains, S1 and S2. The S1 domain binds the host cell receptors, while the S2 domain is responsible for the fusion of the virus with the host cell membrane. Between S1 and S2, there is a hinge region which is targeted by the host cell proteases.

Literature information:


Pubmed ID 20144042
Clinical information No
Disease -
Published year 2010
Journal Journal Of Infectious Diseases
Title Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus
Author Barry Rockx, Eric Donaldson, Matthew Frieman, Timothy Sheahan, Davide Corti
Evidence Table1