Mutation detail:
| Mutation site | D406N |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | P3D |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | RNA-directed RNA polymerase |
| Uniprot protein ID | P03303 |
| Protein length | 460 amino acids |
| Protein description | RdRp replicates the viral genomic RNA on the surface of intracellular membranes. May form linear arrays of subunits that propagate along a strong head-to-tail interaction called interface-I. Covalently attaches UMP to a tyrosine of VPg, which is used to prime RNA synthesis. The positive stranded RNA genome is first replicated at virus induced membranous vesicles, creating a dsRNA genomic replication form. This dsRNA is then used as template to synthesize positive stranded RNA genomes. ss+RNA genomes are either translated, replicated or encapsidated |
Literature information:
| Pubmed ID | 17855535 |
| Clinical information | No |
| Disease | - |
| Published year | 2007 |
| Journal | Journal Of Virology |
| Title | Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 4Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex |
| Author | Miaoqing Shen,Qixin Wang,Yan Yang,Harsh B Pathak,Jamie J Arnold |
| Evidence | the other changes Asp-406 of 3Dpol to Asn. |