Mutation detail:
| Mutation site | N479K |
| Virus | SARS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S Protein |
| Gene ID | 1489668 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | |
| Viral reference sequence | AY291315.1 |
| Drug/antibody/vaccine | Mab CR3014 resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | spike glycoprotein |
| Uniprot protein ID | P59594 |
| Protein length | 1255 amino acids |
| Protein description | The spike protein of SARS coronaviruses is a protein composed of three polypeptide chains and it contains two domains, S1 and S2. The S1 domain binds the host cell receptors, while the S2 domain is responsible for the fusion of the virus with the host cell membrane. Between S1 and S2, there is a hinge region which is targeted by the host cell proteases. |
Literature information:
| Pubmed ID | 16796401 |
| Clinical information | No |
| Disease | - |
| Published year | 2006 |
| Journal | PLoS Med |
| Title | Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants |
| Author | Jan ter Meulen, Edward N van den Brink, Leo L. M Poon, Wilfred E Marissen, Cynthia S. W Leung |
| Evidence | Wild-type and variant fragments were synthesized according to published sequences of SARS-CoV strains. Wild-type S318-510 from strain Frankfurt 1, variant fragments from strains GZ02 (K344R), Sin3408 (S353F), Shanghai LY (R426G and N437D), GZ-C (Y436H), S |