Mutation detail:
| Mutation site | Y499H |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PB1 |
| Gene ID | 23308122 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | LC333183.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PB1 |
| Uniprot protein ID | C3W5X7 |
| Protein length | 757 amino acids |
| Protein description | RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs |
Literature information:
| Pubmed ID | 22577360 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | PLoS pathogens |
| Title | A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon |
| Author | Mila Brum Ortigoza,Oliver Dibben,Jad Maamary,Luis Martinez-Gil,Victor H Leyva-Grado |
| Evidence | A resistant virus was isolated in four passages and complete sequencing of the viral genome revealed a single amino acid change from a tyrosine (Y) to a histidine (H) at position 499 of the PB1 protein (PB1-Y499H). |