AVM

Protein name	ORF1ab polyprotein
Uniprot protein ID	P0C6X7
Protein length	7073 amino acids
Protein description	The Orf1ab polyprotein contains the Orf1a polyprotein and 16 non-structural proteins. The Orf1ab polyprotein and its cleavage products carry out a wide range of activities associated with the viral replication, including ATP binding and breaking down of ADP and phosphate, cysteine-directed endopeptidase, leading to the formation of nonstructural proteins, such as exonuclease that produces ribose- 5-phosphate, methyltransferase for the synthesis of new nucleotides, RNA polymerase for the viral replication, RNA helicase for the removal of super twisting, as well as the regulation of the transcription through binding of zinc. However, the functions of the Orf1ab are the collective functions of the non-structural proteins encoded by the gene of Orf1ab

Pubmed ID	34624207
Clinical information	No
Disease	-
Published year	2021
Journal	Cell Reports
Title	The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
Author	Aaron S. Mendez, Michael Ly, Angélica M. González-Sánchez, Ella Hartenian, Nicholas T. Ingolia
Evidence	Remarkably, however, both the R124A/K125A and R99A mutants gained the ability to translationally repress CoV2L-nLuc (3-fold and 2.4-fold, respectively), although they remained impaired for the translational suppression of HBB-nLuc (Figure 5B).