Mutation detail:
| Mutation site | 11083G>T |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF1ab(NSP6) |
| Gene ID | 43740578 |
| Country | Singapore,Japan,Turkey,Jordan,India,Norway,Australia,South Korea,United Kingdom,Canada,Vietnam,Belgium,Malaysia,China,France,United States,Spain,Brazil,Russia |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC 045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF1ab polyprotein |
| Uniprot protein ID | P0DTC1 |
| Protein length | 7096 amino acids |
| Protein description | ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies. |
Literature information:
| Pubmed ID | 33179934 |
| Clinical information | No |
| Disease | - |
| Published year | 2020 |
| Journal | J Phys Chem Lett. |
| Title | Decoding Asymptomatic COVID-19 Infection and Transmission |
| Author | Rui Wang, Jiahui Chen, Yuta Hozumi, Changchuan Yin, and Guo-Wei Wei |
| Evidence | We first analyze 537 sequences that have either asymptomatic or symptomatic labels. Here, 466 sequences are collected in Japan. The statistical analysis shows that the Pearson correlation coefficient between asymptomatic records and 10083G>T is 0.61 |