AVM

Protein name	Matrix Protein
Uniprot protein ID	P35976
Protein length	335 amino acids
Protein description	The M protein is thought to drive MeV assembly by physically recruiting the RNP and glycoproteins to the host cell plasma membrane. Studies have shown that altered interaction between M and the cytoplasmic tail of H or F affects MeV viral growth, indicating the necessity for contacts between M and the glycoproteins during assembly. Recent structural studies of NDV by cryo-ET and X-ray crystallography demonstrated that the RNP complex is aligned with M protein arrays16. Furthermore, it has been suggested that actin filaments play a role in the MeV assembly and budding process by facilitating the transportation of M-RNP complexes.

Pubmed ID	17217427
Clinical information	No
Disease	SSPE(Subacute sclerosing panencephalitis)
Published year	2007
Journal	Cellular Microbiology
Title	Measles virus nucleocapsid transport to the plasma membrane requires stable expression and surface accumulation of the viral matrix protein
Author	Nicole Runkler,Christine Pohl,Sibylle Schneider-Schaulies,Hans-Dieter Klenk,Andrea Maisner
Evidence	Although MV101A was rapidly degraded in infected cells, the turnover of MV101A was slower than in cells transfected to express M protein alone suggesting that virus infection either slows down the degradation machinery or MV101A is stabilized by other vir