Mutation detail:
| Mutation site | Y310D/L296I |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | H |
| Gene ID | 1489801 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | Z66517.1 |
| Drug/antibody/vaccine | mAb-BH38 resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin Protein |
| Uniprot protein ID | P08362 |
| Protein length | 617 amino acids |
| Protein description | Hemagglutinin Protein attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis. |
Literature information:
| Pubmed ID | 23300970 |
| Clinical information | No |
| Disease | - |
| Published year | 2013 |
| Journal | PLoS One |
| Title | Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies |
| Author | Patrycja J Lech,Gregory J Tobin,Ruth Bushnell,Emily Gutschenritter,Linh D Pham |
| Evidence | Y310D and L296I were identified as escape mutations in a BH38 escape MV variant |