Mutation detail:
| Mutation site | D1324E |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | L |
| Gene ID | 1489802 |
| Country | Canada |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | D6 |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AF266288.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Large Polymerase Protein |
| Uniprot protein ID | P12576 |
| Protein length | 2183 amino acids |
| Protein description | The viral polymerase (an RNA-dependent RNA polymerase, RdRp) or large protein is coded by the L gene. It catalyzes RNA synthesis, polymerization, capping, polymerization, methylation and polyadenylation. The negative sense RNA is transcribed directly into mRNA without forming any DNA intermediate. |
Literature information:
| Pubmed ID | 30291564 |
| Clinical information | No |
| Disease | SSPE(Subacute sclerosing panencephalitis) |
| Published year | 2018 |
| Journal | Journal of NeuroVirology |
| Title | Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada |
| Author | K Pabbaraju,K Fonseca,S Wong,M W Koch,J T Joseph |
| Evidence | The L protein is more conserved than other proteins; however, several unique mutations found in the Alberta strain were absent in the wild type and other SSPE D6 strains including S115L, V707I, V739I, R1091G, V1276M, T1312A, D1324E, H1420N, R1503R/K, G1706S, T1809I, S1931N, I2017T, and I2149L. |