AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	23116787
Clinical information	No
Disease	-
Published year	2012
Journal	Enfermedades Infecciosas y Microbiologia Clinica
Title	Influenza A(H1N1)pdm09 virus: viral characteristics and genetic evolution
Author	Andres Antona, Francisco Pozoc, Jordi Niubod, Inmaculada Casasc and Tomas Pumarola
Evidence	During the 2010-2011 influenza season, an additional genetic group characterized by amino acid substitutions E172K, S203T, K308E in HA, often with V47I mutation, was identified in Spain,22 indicating the importance of performing regional influenza surveillance.