Mutation detail:
| Mutation site | E41G |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | 3A |
| Gene ID | 5758809 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | C |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | GU219984.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Protein 3A |
| Uniprot protein ID | A0A2P1DXU1 |
| Protein length | 75 amino acids |
| Protein description | Protein 3A localizes the viral replication complex to the surface of membranous vesicles. It inhibits host cell endoplasmic reticulum-to-Golgi apparatus transport and causes the disassembly of the Golgi complex, possibly through GBF1 interaction. This would result in depletion of MHC, trail receptors and IFN receptors at the host cell surface. |
Literature information:
| Pubmed ID | 27743961 |
| Clinical information | No |
| Disease | - |
| Published year | 2016 |
| Journal | Virology |
| Title | Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells |
| Author | Yury A Bochkov,Kelly Watters,Sarmila Basnet,Shakher Sijapati,Marchel Hill |
| Evidence | Figure2 |