Mutation detail:
| Mutation site | 22713C>T |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | India |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 33368386 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | JOURNAL OF MEDICAL VIROLOGY |
| Title | Dynamic tracking of variant frequencies depicts the evolution of mutation sites amongst SARS-CoV-2 genomes from India |
| Author | Shenu Hudson B,Vaishnavi Kolte,Azra Khan,Gaurav Sharma |
| Evidence | The mutational probabilities of these 118 sites across all time points (month-wise) were visualized using a clustered heatmap where six clusters were obtained with 4, 3, 2, 5, 5, and 99 sites per cluster (Figure 1A,B and Table S2). |