Mutation detail:
| Mutation site | 22812A>C |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | Brazil,USA |
| Mutation type |
- |
| Genotype/subtype/clade | 20J |
| Sample |
Human |
| Variants | Gamma |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34044192 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | INFECTION GENETICS AND EVOLUTION |
| Title | E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil |
| Author | Patrícia Aline Grohs Ferrareze, Vinicius Bonetti Franceschi, Amanda de Menezes Mayer, Gabriel Dickin Caldana, Ricardo Ariel Zimerman |
| Evidence | A hallmark of these Brazilian lineages is the presence of multiple lineage-defining mutations per lineage (Table 1 ). |