AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	23280524
Clinical information	Yes
Disease	-
Published year	2013
Journal	J Med Virol
Title	Clinical and molecular characteristics of the 2009 pandemic influenza H1N1 infection with severe or fatal disease from 2009 to 2025 in Shenzhen, China
Author	Chunli Wu,Xiaowen Cheng,Xin Wang,Xing Lv,Fan Yang
Evidence	Some other amino acid changes, such as Q293H in HA, K340N, E627K, and D701N in PB2, which may be associated with viral virulence [Jagger et al., 2010; World Health Organization, 2010b], were not observed in our study.