Mutation detail:
| Mutation site | 4277A>C |
| Virus | Human rhinovirus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | 2C |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | 2C (P2-C) |
| Uniprot protein ID | P03303 |
| Protein length | 330 amino acids |
| Protein description | P2-C induces and associates with structural rearrangements of intracellular membranes. Displays RNA-binding, nucleotide binding and NTPase activities. May play a role in virion morphogenesis and viral RNA encapsidation by interacting with the capsid protein VP3. |
Literature information:
| Pubmed ID | 18541697 |
| Clinical information | No |
| Disease | - |
| Published year | 2008 |
| Journal | RNA |
| Title | The cis-acting replication elements define human enterovirus and rhinovirus species |
| Author | Samuel Cordey,Daniel Gerlach,Thomas Junier,Evgeny M Zdobnov,Laurent Kaiser |
| Evidence | As shown in Figure 2, A4277C (Lys-Gln), A4278C (Lys-Thr), A4279C (Lys-Asn), and A4286T (Thr-Ser) caused a decrease of six- to sevenfold in viral replication |