Mutation detail:
| Mutation site | 23598_23599ins |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | Russia |
| Mutation type |
- |
| Genotype/subtype/clade | GR |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34072569 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Viruses |
| Title | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| Author | Anna Gladkikh, Anna Dolgova, Vladimir Dedkov, Valeriya Sbarzaglia, Olga Kanaeva |
| Evidence | Pairwise comparison of the NW variant genomes with the Wuhan-Hu-1 reference genome (NCBI GenBank accession number NC_045512.2) enabled identification of a number of features. In addition to synonymous and nonsynonymous substitutions, these included a deletion (21969DEL21995, Figure 2a) and an insertion (23598IN23599, Figure 2b) in both NW isolates (SPb-117, P-16, Table 1). Some mutations observed, including indels, occurred in the viral spike-protein gene. |