AVM

Protein name	Nonstructural Protein 1
Uniprot protein ID	C3W611
Protein length	219 amino acids
Protein description	The non-structural protein 1 (NS1) is a crucial influenza A virus immune regulator that antagonizes antiviral response. The NS1 protein counteracts the production of IFNs and the activities of IFN-induced proteins that restrict influenza virus replication. Furthermore, NS1 is a multifunctional regulatory viral protein that plays a critical role as a posttranscriptional regulatory factor in the life cycle of influenza virus; specifically, binding virion RNA. NS1 protein consists of 2 distinct functional domains connected by a flexible linker region (LR): an N-terminal RNA- binding domain (RBD, aa 1-73) and a C-terminal effector domain (ED, aa 74-207). The nucleotide sequence (NLS) (aa 35-41) overlaps the sequences needed for dsRNA binding.

Pubmed ID	19451021
Clinical information	No
Disease	-
Published year	2009
Journal	J Clin Virol
Title	Genetic microheterogeneity of emerging H275Y influenza virus A (H1N1) in Toronto, Ontario, Canada from the 2007-2010 respiratory season
Author	A Eshaghi,S Bolotin,L Burton,D E Low,T Mazzulli,S J Drews
Evidence	Strains exhibiting mutations A209T and R224G in the NS gene are denoted with a square, strains exhibiting only the A209T mutation are denoted with a triangle and strains exhibiting only the R224G mutation are denoted with a circle. All study strains used in this analysis belonged to Clade 2B, which is divided into two main branches. Toronto H275 strains cluster with A/Brisbane/59/2007, while Toronto H275Y strains cluster in a separate group with A/South Australia/1/2008 and A/Wisconsin/01/2008 and have a common A189T mutation in the HA gene. Toronto H275Y strains listed in this figure as well A/South Australia/1/2008 and A/Wisconsin/01/2008 have A209T and R224G mutations in the NS1 gene. A minority of H275 strains has either A209T or R224G mutations in the NS1 gene.