Mutation detail:
| Mutation site | D510G |
| Virus | MERS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S Protein |
| Gene ID | 1489668 |
| Country | Korea |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | JX869059.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
hinder |
| Transmission mechanism | 11 of these genomes have an I529T mutation in RBD, and 1 has a D510G mutation. Strikingly, both mutations result in reduced affinity of RBD to human CD26 compared to wild-type RBD, as measured by surface plasmon resonance analysis and cellular binding ass |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike Glycoprotein |
| Uniprot protein ID | K9N5Q8 |
| Protein length | 1353 amino acids |
| Protein description | The spike protein of coronaviruses is a protein composed of three polypeptide chains and it contains two domains, S1 and S2. The S1 domain binds the host cell receptors, while the S2 domain is responsible for the fusion of the virus with the host cell membrane. Between S1 and S2, there is a hinge region which is targeted by the host cell proteases. The S1 is composed of an N-terminal domain (S1-NTD) which binds sugar and protein receptors, and a C- terminal domain (S1-CTD) which is responsible for binding host cell protein receptors. The S2 binds to the S1-NTD, contains heptad hydrophobic) repeat regions and a fusion peptide which is located downstream of S1-NTD. |
Literature information:
| Pubmed ID | 26933050 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2016 |
| Journal | mBio |
| Title | Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak |
| Author | Yuri Kim,Shinhye Cheon,Chan-Ki Min,Kyung Mok Sohn,Ying Jin Kang |
| Evidence | We isolated 13 new viral genomes from 14 infected patients treated at a hospital and found that 12 of these genomes possess a point mutation in the receptor-binding domain (RBD) of viral spike (S) protein. Specifically, 11 of these genomes have an I529T m |