Mutation detail:
| Mutation site | 4277A>G |
| Virus | Human rhinovirus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | 2C |
| Gene ID | 1461213 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | B |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001490.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | 2C (P2-C) |
| Uniprot protein ID | P03303 |
| Protein length | 330 amino acids |
| Protein description | P2-C induces and associates with structural rearrangements of intracellular membranes. Displays RNA-binding, nucleotide binding and NTPase activities. May play a role in virion morphogenesis and viral RNA encapsidation by interacting with the capsid protein VP3. |
Literature information:
| Pubmed ID | 18541697 |
| Clinical information | No |
| Disease | - |
| Published year | 2008 |
| Journal | RNA |
| Title | The cis-acting replication elements define human enterovirus and rhinovirus species |
| Author | Samuel Cordey,Daniel Gerlach,Thomas Junier,Evgeny M Zdobnov,Laurent Kaiser |
| Evidence | The replication is further reduced (30- to 50-fold) with the following mutations: A4277G (Lys-Glu), A4278T (Lys-Ile), AA4277/8GG (Lys-Gly), A4286C (Thr-Pro), and A4290G (Thr-Ala). |