Mutation detail:
| Mutation site | M582L |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PA |
| Gene ID | 23308128 |
| Country | Mexico |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_026437.1 |
| Drug/antibody/vaccine | Adamantane resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PA |
| Uniprot protein ID | C3W5X6 |
| Protein length | 716 amino acids |
| Protein description | PA Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. |
Literature information:
| Pubmed ID | 19465683 |
| Clinical information | No |
| Disease | - |
| Published year | 2009 |
| Journal | Science |
| Title | Antigenic and Genetic Characteristics of the Early Isolates of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans |
| Author | Rebecca J. Garten,C. Todd Davis,Colin A. RussellBo Shu,Stephen Lindstrom |
| Evidence | Analysis across the genomes of the 2009 A(H1N1) viruses from Mexico and the USA to date, found five minor genome variants: (i) the consensus sequence, (ii) T373I mutation in the NP paired with M582L mutation in the PA, (iii) amino acid substitutions of V106I and N247D in the NA (N2 numbering) paired with V100I in the NP and (iv) amino acid substitutions of S206T in the HA1 (H3 numbering) clustering with both V106I and N247D in the NA (N2 numbering), V100I in the NP and I123V in the NS1, and (v) amino acid substitutions of S91P, V323I (H3 numbering) together with S224P in the PA (Table S2). |