Mutation detail:
| Mutation site | S29P |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | SH |
| Gene ID | 1494473 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | KF973319.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Small Hydrophobic Protein |
| Uniprot protein ID | P0DOE5 |
| Protein length | 64 amino acids |
| Protein description | Small Hydrophobic Proteina(SH) forms a homopentameric ion channel displaying low ion selectivity.SH may play a role in virus morphogenesis and pathogenicity at various stages of the viral life cycle. SH accumulates at the membrane of the Golgi apparatus in infected cells and may facilitate virus release by modifying the secretory pathway. SH may enhance host membrane permeability and disrupt cellular ion homeostasis, which can be sensed as damage-associated molecular patterns/danger signals, triggering NLRP3 inflammasome activation and inflammatory immune response. SH also inhibits host TNFA-mediated signaling pathway and may delay apoptosis, allowing time for the virus to replicate. |
Literature information:
| Pubmed ID | 24741088 |
| Clinical information | No |
| Disease | - |
| Published year | 2014 |
| Journal | Journal Of Virology |
| Title | Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure |
| Author | Yonatan H Grad, Ruchi Newman, Michael Zody, Xiao Yang, Ryan Murphy |
| Evidence | FIG 2 |