Mutation detail:
| Mutation site | S58A |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | M2 |
| Gene ID | 1494476 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | M74568.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Matrix (M2/22K) |
| Uniprot protein ID | P04545 |
| Protein length | 194 amino acids |
| Protein description | Matrix (M2/22K) acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Matrix (M2/22K) plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate host NF kappa-B through association with host RELA. |
Literature information:
| Pubmed ID | 11711610 |
| Clinical information | No |
| Disease | - |
| Published year | 2001 |
| Journal | Journal of virology |
| Title | Respiratory Syncytial Virus M2-1 Protein Requires Phosphorylation for Efficient Function and Binds Viral RNA during Infection |
| Author | Tara L. Cartee,Gail W. Wertz |
| Evidence | The activity of the S58A, S61A, and T56A S58A mutants remained below that of the wt at all three input plasmid levels. The S61A mutant, which was not as impaired as the S58A and T56A S58A mutants, reached readthrough levels of about 55% |