Mutation detail:
Mutation site | T110A |
Virus | Human respiratory syncytial virus |
Mutation level ![]() |
Amino acid Level |
Gene/protein/region type | M2 |
Gene ID | 1494476 |
Country | - |
Mutation type ![]() |
nonsynonymous mutation |
Genotype/subtype/clade | A |
Sample ![]() |
cell line |
Variants | - |
Viral reference sequence | AY911262.1 |
Drug/antibody/vaccine | - |
Transmissibility ![]() |
- |
Transmission mechanism | - |
Pathogenicity ![]() |
- |
Pathogenicity mechanism | - |
Immune escape mutation | - |
Immune escape mechanism | - |
RT-PCR primers probes | - |
Protein detail:
Protein name | Matrix (M2/22K) |
Uniprot protein ID | P04545 |
Protein length | 194 amino acids |
Protein description | Matrix (M2/22K) acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription. Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription. Preferentially binds to poly(A)-rich sequences. Matrix (M2/22K) plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding. Also, can activate host NF kappa-B through association with host RELA. |
Literature information:
Pubmed ID | 33684421 |
Clinical information | No |
Disease | - |
Published year | 2021 |
Journal | Virus Research |
Title | Steady-state persistence of respiratory syncytial virus in a macrophage-like cell line and sequence analysis of the persistent viral genome |
Author | Ximena Ruiz-Gomez, Joel Armando Vazquez-Perez, Oscar Flores-Herrera, Mercedes Esparza-Perusquia, Carlos Santiago-Olivares |
Evidence | Table 3 |