Mutation detail:
| Mutation site | N187S |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | HA |
| Gene ID | 23308115 |
| Country | Oceania, South East Asia and South Africa |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | CY033622.1 |
| Drug/antibody/vaccine | oseltamivir |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin |
| Uniprot protein ID | C3W627 |
| Protein length | 566 amino acids |
| Protein description | The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. |
Literature information:
| Pubmed ID | 19501261 |
| Clinical information | No |
| Disease | - |
| Published year | 2009 |
| Journal | Antiviral Research |
| Title | Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa |
| Author | Aeron C Hurt,Joanne Ernest,Yi-Mo Deng,Pina Iannello,Terry G Besselaar |
| Evidence | As well as the H274Y mutation in the NA conferring oseltamivir resistance, the majority of mutant viruses (87%) collected in Australia after July 2008 also contained two amino acid differences in the HA gene (N187S and G189N) compared to H274Y viruses circulating in the Northern Hemisphere or Australia prior to that time |