AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	19864389
Clinical information	No
Disease	-
Published year	2010
Journal	JOURNAL OF VIROLOGY
Title	Generation of Live Attenuated Novel Influenza Virus A/California/7/09 (H1N1) Vaccines with High Yield in Embryonated Chicken Eggs
Author	Zhongying Chen,Weijia Wang,Helen Zhou,Amorsolo L. Suguitan, Jr.,
Evidence	These data demonstrate that the K119E and A186D substitution mutations in the HA of A/CA/07/09 (H1N1) conferred high rates of growth in eggs without altering virus antigenicity or immunogenicity, making them attractive as potential vaccine candidates for the swine origin 2009 H1N1 virus.