Mutation detail:
| Mutation site | G301M |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF50 |
| Gene ID | 1487658 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB097933.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Envelope Glycoprotein M |
| Uniprot protein ID | Q77NP2 |
| Protein length | 435 amino acids |
| Protein description | The ORF50 gene of the varicella-zoster virus (VZV) encodes glycoprotein M (gM), which is conserved among all herpesviruses and is important for the cell-to-cell spread of VZV. Important features are its 6-8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. |
Literature information:
| Pubmed ID | 20106918 |
| Clinical information | No |
| Disease | - |
| Published year | 2010 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Characterization of the Varicella-Zoster Virus ORF50 Gene, Which Encodes Glycoprotein M |
| Author | Tomohiko Sadaoka,Tatsuya Yanagi,Koichi Yamanishi,Yasuko Mori |
| Evidence | In addition, we found that two amino acid mutations of gM, V42P and G301M, blocked gM's maturation and transport to the trans-Golgi network, which is generally recognized as the viral assembly complex. |