AVM

Protein name	Membrane Glycoprotein
Uniprot protein ID	P0DTC5
Protein length	222 amino acids
Protein description	The membrane protein is present in high amounts out of all proteins in coronaviruses . Its length spans to about 220-260 amino acids with a short length N terminal domain, attached to triple transmembrane domains that are further connected to a carboxyl-terminal domain and belong to the N-linked glycosylated proteins with a conserved domain of 12 amino acids. Out of the three TDM, the first one is capable enough to encourage self-association of M proteins, improved membrane affinity, and retention in Golgi. The membrane protein is a transmembrane glycoprotein, is the most abundant structural protein in the virus particle and has been suggested as an antiviral drug target.

Pubmed ID	33086379
Clinical information	No
Disease	-
Published year	2020
Journal	CLINICAL INFECTIOUS DISEASES
Title	Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal tract
Author	Pengcheng Du, Chuan Song, Rui Li, Yangzi Song, Jiarui Li
Evidence	We further analyzed the sequence data for the presence of iSNVs in the three samples. We detected four iSNVs (C8481T, C22000A, T26975G and G28812T - Figure 1B) in the pharyngeal swab and sputum samples, three (C8481T, C22000A, and G28812T) of which have been identified as SNP sites previously. [7] These four iSNVs were located in the ORF1a, S, M and N genes, respectively, and led to nonsynonymous mutations (Figure 1B)