Mutation detail:
| Mutation site | 27198G>T |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | M |
| Gene ID | 43740571 |
| Country | India |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Membrane Glycoprotein |
| Uniprot protein ID | P0DTC5 |
| Protein length | 222 amino acids |
| Protein description | The membrane protein is present in high amounts out of all proteins in coronaviruses . Its length spans to about 220-260 amino acids with a short length N terminal domain, attached to triple transmembrane domains that are further connected to a carboxyl-terminal domain and belong to the N-linked glycosylated proteins with a conserved domain of 12 amino acids. Out of the three TDM, the first one is capable enough to encourage self-association of M proteins, improved membrane affinity, and retention in Golgi. The membrane protein is a transmembrane glycoprotein, is the most abundant structural protein in the virus particle and has been suggested as an antiviral drug target. |
Literature information:
| Pubmed ID | 33705994 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | COMPUTERS IN BIOLOGY AND MEDICINE |
| Title | A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics |
| Author | R. Prathiviraj, S. Saranya, M. Bharathi, and P. Chellapandi |
| Evidence | Forty-one protein mutations were identified in 12 Indian SARS-CoV-2 isolates by analysis of genome variations across 460 genome sequences obtained from 30 geographic sites in India. Two unique mutations such as W6152R and N5928H found in exonuclease of Surat (GBRC275b) and Gandhinagar (GBRC239) isolates |