Mutation detail:
| Mutation site | E368A |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | L |
| Gene ID | 1489802 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | D3 |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AB016162.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Large Polymerase Protein |
| Uniprot protein ID | P12576 |
| Protein length | 2183 amino acids |
| Protein description | The viral polymerase (an RNA-dependent RNA polymerase, RdRp) or large protein is coded by the L gene. It catalyzes RNA synthesis, polymerization, capping, polymerization, methylation and polyadenylation. The negative sense RNA is transcribed directly into mRNA without forming any DNA intermediate. |
Literature information:
| Pubmed ID | 16858143 |
| Clinical information | No |
| Disease | SSPE(Subacute sclerosing panencephalitis) |
| Published year | 2006 |
| Journal | Microbiology and Immunology |
| Title | Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE |
| Author | Hak Hotta,Kenji Nihei,Yu-ichi Abe,Seiichi Kato,Da-Peng Jiang |
| Evidence | Fig.3 |