Mutation detail:
| Mutation site | 27612C>T |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF7a |
| Gene ID | 43740573 |
| Country | India |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF7a protein |
| Uniprot protein ID | P0DTC7 |
| Protein length | 121 amino acids |
| Protein description | The orf 7a of SARS-CoV-2 is a transmembrane protein with four regions from the N-terminal: 1) the first 15 amino acids form a signal peptide which is hydrolyzed by the infected host cells; 2) the amino acids from 16 to 96 constitute the intracellular domain; 3) the 97- 117 amino acids are hydrophobic amino acids constituting a transmembrane domain; and 4) the last five amino acids constitute the C- terminal of the orf7a. The orf7a interacts with the S, M, E, and the orf3a proteins, which suggest a role of the protein in the assembling of the virus and in the binding and invasion of the virus to the host cells. |
Literature information:
| Pubmed ID | 33555895 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2021 |
| Journal | journal of proteome research |
| Title | Proteo-Genomic Analysis of SARS-CoV-2: A Clinical Landscape of Single-Nucleotide Polymorphisms, COVID-19 Proteome, and Host Responses |
| Author | Sheetal Tushir,Sathisha Kamanna,Sujith S. Nath,Aishwarya Bhat,Steffimol Rose |
| Evidence | Our study confirms the mutability of SARS-CoV-2 showing multiple single-nucleotide polymorphisms. NGS analysis detected 27 mutations, of which 14 are synonymous, 11 are missense, and 2 are extragenic in nature.(Table S1) |