Mutation detail:
| Mutation site | I92T |
| Virus | Human rhinovirus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | P2-B |
| Gene ID | 1493933 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | L24917.1 |
| Drug/antibody/vaccine | PI4K3b inhibitor resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | P2-B Polypeptide |
| Uniprot protein ID | P07210 |
| Protein length | 95 amino acids |
| Protein description | P2-B plays an essential role in the virus replication cycle by acting as a viroporin.P2-B creates a pore in the host reticulum endoplasmic and as a consequence releases Ca2+ in the cytoplasm of infected cell. In turn, high levels of cytoplasmic calcium may trigger membrane trafficking and transport of viral ER-associated proteins to viroplasms, sites of viral genome replication. |
Literature information:
| Pubmed ID | 30209171 |
| Clinical information | No |
| Disease | Asthmatic Exacerbations, Chronic Obstructive Pulmonary Disease |
| Published year | 2018 |
| Journal | Journal Of Virology |
| Title | A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication |
| Author | Pascal S Roulin,Luca P Murer,Urs F Greber |
| Evidence | We identified a PI4K3b inhibitor-resistant RV-A16 variant with a single point mutation in the conserved 2B protein near the cytosolic carboxy terminus, isoleucine 92 to threonine (termed 2B[I92T]). |