Mutation detail:
| Mutation site | del27848-28229 |
| Virus | SARS-CoV-2 |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF8 |
| Gene ID | 43740577 |
| Country | Singapore |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF8 protein |
| Uniprot protein ID | P0DTC8 |
| Protein length | 121 amino acids |
| Protein description | The SARS-CoV-2 ORF8 gene spans 366 nucleotides (nt), is located between position 27,894 and 28,259 of the virus genome, following the ORF7b and preceding the N genes, respectively. The ORF8 gene is part of a hypervariable genomic region of - 430 bp in length that has been recognized as a recombination hotspot, also highly susceptible to deletions and nt substitutions. ORF8 protein comprehends an N-terminal signal peptide for transmembrane (TM) import and secretion, an internal -sandwich core and a C-terminal TM region followed by a stretch of basic residues. |
Literature information:
| Pubmed ID | 32822564 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2020 |
| Journal | The Lancet |
| Title | Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study |
| Author | Barnaby E Young,Siew-Wai Fong,Yi-Hao Chan,Tze-Minn Mak,Li Wei Ang |
| Evidence | Patients with del382-variant infection presented later after symptom onset, with a lower median temperature, and with less systemic inflammation according to baseline laboratory investigations than the wild-type only group. |